JINGLIN JI

Graduate Student

she/her/hers

EDUCATION

B.S. Biology and B.S.P.H. Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC

Doris is a graduate student at Moss Laboratories.

Doris’ work focuses on Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) which are the most widely used chemogenetically engineered proteins, using mutated human muscarinic receptors that are not activated by endogenous neurotransmitters but exclusively via clozapine N-oxide (CNO). GiDREADDs inhibit axonal release of neurotransmitter, while GsDREADDs activate neuronal activity. Doris is using Aldh1l1-cre Gi-DREADD/Gs-DREADD mice with Cre recombinase-inducible astrocyte-specific expression of GiDREADD/GsDREADD to investigate the effects of astrocytic Gi-DREADD/Gs-DREADD activation on animal behavior, EEG power, neuronal excitability and the phosphorylation of astrocytic and neuronal substrates.

Outside of the laboratories, Doris has been a ballerina for over twenty years! She also loves doing yoga, painting, and floral designing in her spare time.