2022

Analyzing the mechanisms that facilitate the subtype-specific assembly of γ-aminobutyric acid type A receptors

Catherine Choi, Joshua L. Smalley, Abigail H. S. Lemons, Qiu Ren, Christopher E. Bope, Jake S. Dengler, Paul A. Davies and Stephen J. Moss

Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus

Kathryn L Lee, Krithika Abiraman, Christopher Lucaj, Thomas A Ollerhead, Nicholas J Brandon, Tarek Z Deeb, Jamie Maguire, Stephen J Moss

Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum

Komatsu, A. Iida, I., Ito, G., Harada, F., Kishikawa, S., Moss, S.J., Maeda, T., and Terunuma, M.

Preventing phosphorylation of the GABAAR β3 subunit compromises the behavioural effects of neuroactive steroids

Vein, T., Ackley, M., Doherty, D., Moss, S.J. and Davies P.A.

The human ARHGEF9 mutation syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit

Hines, D.J., Contreras, D., Garcia, B., Barker, J.S., Boren, A.J., El-Achkar, C., Moss, S.J. and Hines. R.M.

2021

KCC2 is required for the survival of mature neurons but not for their development

Georgina Kontou, Shu Fun Josephine Ng, Ross A. Cardarelli, Jack H. Howden, Catherine Choi, Qiu Ren, Miguel A. Rodriguez Santos, Christopher E. Bope, Jake S. Dengler, Matt R. Kelly, Paul A. Davies, Josef T. Kittler, Nicholas J. Brandon, Stephen J. Moss, Joshua L. Smalley

Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)

Madjroh N, Mellou E, Davies PA, Söderhielm PC, Jensen AA

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)

Madjroh N, Mellou E, Æbelø L, Davies PA, Söderhielm PC, Jensen AA

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes

Madjroh N, Davies PA, Smalley JL, Kristiansen U, Söderhielm PC, Jensen AA

Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid receptors

Durkin, E.J., Muessig, L., Herlt, T., Lumb, L., Patel, R., Thomas, P., Bright, D., Jurd, R., Moss, S.J., Dickenson, A.H., Cacucci, F. and Smart T.G

2020

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 Form Brain Plasma Membranes

Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Stephen J. Moss

Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

Tejeda, G.S., Whiteley, W.L. Deeb,T.Z., Bürli,R.L., Moss, S.J., Sheridan, E., Brandon, N.J. and Baillie, G.S.

Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders

Erli, F., Palmos, A.B., Raval, P., Mukherjee, J., Sellers, K.J., Gatford, N.J.F., Moss, S.J, Brandon, N.J., Penzes, P., Srivastava, D.

Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling

Li, X., Terunuma, M., Deeb, T.G., Wiseman, S.H., Pangalos, M.N., Nairn, A.C. Moss, S.J. and Slesinger, P.A.

Phosphorylation of the α2 subunit on serine 359 regulates binding of γ-aminobuytric acid type A receptors collybistin and gephyrin

Nakamura, Y., Morrow D.H., Henley, J.M., Wilkinson, K., and Moss S.J.

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Althaus, A.L, Ackley, A., Belfort, G.M., Gee, S.M., Dai, J., Nguyen, D.P., Tatiana M. Kazdoba, T.M., Modgil, A., Davies, P.A., Moss, S.J., Salituro, F.G., Hoffmann, E., Hammond, R.S., J. Robichaud, A.J., Quirk, M.C. and Doherty, J.J.

2019

A Computationally Inspired In-vivo Approach Identifies a Link Between Amygdalar Transcriptional Heterogeneity, Socialization and Anxiety

Aaron Goldman, Joshua L. Smalley, Meeta Mistry, Harald Krenzlin, Hong Zhang, Andrew Dhawan, Barbara Caldarone, Stephen J. Moss, David A. Silbersweig, Sean E. Lawler & Ilana M. Braun

Inhibitory Synapse Formation at the Axon Initial Segment

Anna J. Nathanson, Paul A. Davies, and Stephen J. Moss

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Yvonne E. F. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, and Stephen J. Moss

Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, and Stephen J. Moss

Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors

Parakala ML, Zhang Y, Modgil A, Chadchankar J, Vien TN, Ackley MA, Doherty JJ, Davies PA, Moss SJ

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

Déborah Huyghe, Andrew R. Denninger, Caroline M. Voss, Pernille Frank, Ning Gao, Nocholas Brandon, Helle S. Waagespetersen, Andrew D. Ferguson, Menelas Pangalos, Peter Doig, and Stephen J. Moss

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Modgil A, Vien TN, Ackley MA, Doherty JJ, Moss SJ, Davies PA

2018

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

Moore YE, Deeb TZ, Chadchankar H, Brandon NJ, Moss SJ

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization

Rifkin RA, Huyghe D, Li X, Parakala M, Aisenberg E, Moss SJ, Slesinger PA

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, Wood MW, Kulic I, Wellington CL

2017

Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice

Melón LC, Hooper A, Yang X, Moss SJ, Maguire J.

The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity

Cardarelli RA, et. al.

Molecular architecture of potassium chloride co-transporter KCC2

Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A.

Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAAreceptors at inhibitory synapses

Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ.

N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation

Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ

Seizing control of KCC2: A new therapeutic target for epilepsy

Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant

Wobst HJ, Delsing L, Brandon NJ, Moss SJ

G protein-gated potassium channels: A link to drug addiction

Rifkin RA, Moss SJ, Slesinger PA

Deficits in the activity of presynaptic γ-Aminobutyric acid type B receptors contribute to altered neuronal excitability in Fragile X Syndrome

Kang JY, Chadchankar J, Vien TN, Mighdoll MI, Hyde TM, Mather RJ, Deeb TZ, Pangalos MN, Brandon NJ, Dunlop J, Moss SJ

2016

Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism

Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA

Effects of Gabra2 point mutations on alcohol intake: Increased binge-like and blunted chronic drinking by mice

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA

Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G

Compromising KCC2 transporter activity enhances the development of continuous seizure activity

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ

Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR α2 subunit knock-in mouse

Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ

A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons

Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA

Copper and protons directly activate the zinc-activated channel

Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA

2015

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ

Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ

KCC2 activity is critical in limiting the onset and severity of status epilepticus

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ

Regulation of GABAARs by phosphorylation

Nakamura Y, Darnieder LM, Deeb TZ, Moss SJ

Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling

Terunuma M, Haydon PG, Pangalos MN, Moss SJ

2014

Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by G-aminobutyric type B receptors

Huyghe D, Nakamura Y, Terunuma M, Faideau M, Haydon P, Pangalos NM, Moss SJ

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A

Phosphorylation of GABAAreceptors influences receptor trafficking and neurosteroid actions

Comenencia-Ortiz E, Moss SJ, Davies PA

Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors

Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ

Neural basis of benzodiazepine reward: Requirement for α2 containing GABAA receptors in the nucleus accumbens

Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U

Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ

2013

The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABAA-receptor γ2 subunit

Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ